4-Methylphenyl isocyanate → HCID 21101796, compound

HRID 1353362Notes

Reaction equation

HRID 1353362 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[C:18]1([CH3:27])[CH:23]=[CH:22][C:21]([N:24]=[C:25]=[O:26])=[CH:20][CH:19]=1>C(Cl)Cl>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:25]([NH:24][C:21]4[CH:22]=[CH:23][C:18]([CH3:27])=[CH:19][CH:20]=4)=[O:26])[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 693254-Methylphenyl isocyanateHCID 7383897-Chloro-4-(piperazin-1-yl)quinoline

Product 1

HCID 21101796HCID 21101796, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

7-Chloro-4-(piperazin-1-yl)quinoline (62 mg, 0.25 mmol) and p-tolyl isocyanate (32 μL, 0.25 mmol) in CH2Cl2 (5 mL) are reacted according to method C yielding the title product as a colorless solid.

Sources & evidence

ORD record
ord-eb567d5a1c374db5b7da6b52126dbd9c
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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