HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Tolyl isocyanate → 7-Chloro-4-[4-(2-methylphenylaminocarbonyl)piperazin-1-yl]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Tolyl isocyanate | HCID 69194 | — |
| Reactant | 7-Chloro-4-(piperazin-1-yl)quinoline | HCID 738389 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-Chloro-4-[4-(2-methylphenylaminocarbonyl)piperazin-1-yl]quinoline | HCID 21101759 | — |
Reaction Steps
7-Chloro-4-(piperazin-1-yl)quinoline (62 mg, 0.25 mmol) and o-tolyl isocyanate (31 μL, 0.25 mmol) in CH2Cl2 (5 mL) are reacted according to method C yielding the title product as colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-6257209c864f419aa4535fbde737e486 |
| Source note | uspto-grants-2007_05 |