HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Benzyloxy)phenyl isocyanate → 4-[4-(4-Benzyloxyphenylaminocarbonyl)piperazin-1-yl]-7-chloroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Benzyloxy)phenyl isocyanate | HCID 256268 | — |
| Reactant | 7-Chloro-4-(piperazin-1-yl)quinoline | HCID 738389 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[4-(4-Benzyloxyphenylaminocarbonyl)piperazin-1-yl]-7-chloroquinoline | HCID 21101689 | — |
Reaction Steps
7-Chloro-4-(piperazin-1-yl)quinoline (62 mg, 0.25 mmol) and 4-benzyloxyphenyl isocyanate (68 mg, 0.30 mmol) in THF (10 mL) are reacted according to method C yielding the title product as a yellow solid after column chromatography with hexane-EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-577c554a8e9242efbe850bd89c978717 |
| Source note | uspto-grants-2007_05 |