HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenethyl isocyanate → 7-Chloro-4-[4-(phenethylaminocarbonyl)piperazin-1-yl]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenethyl isocyanate | HCID 160602 | — |
| Reactant | 7-Chloro-4-(piperazin-1-yl)quinoline | HCID 738389 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-Chloro-4-[4-(phenethylaminocarbonyl)piperazin-1-yl]quinoline | HCID 21101806 | — |
Reaction Steps
7-Chloro-4-(piperazin-1-yl)quinoline (62 mg, 0.25 mmol) and phenethyl isocyanate (45 μL, 0.30 mmol) in THF (10 mL) are reacted according to method C yielding the title product as a colorless oil after column chromatography with hexane-EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-ffb00c15796a44caa73bd3bdcdbf4647 |
| Source note | uspto-grants-2007_05 |