HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 7-Chloro-4-[4-(2-chlorobenzylaminocarbonyl)piperazin-1-yl]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chlorobenzylamine | HCID 66648 | — |
| Reactant | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| Reactant | 7-Chloro-4-(piperazin-1-yl)quinoline | HCID 738389 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | 7-Chloro-4-[4-(2-chlorobenzylaminocarbonyl)piperazin-1-yl]quinoline | HCID 21101756 | — |
Reaction Steps
2-Chlorobenzylamine (60 μL, 0.5 mmol), 4-nitrophenyl chloroformate (101 mg, 0.5 mmol), triethylamine (238 μL, 1.7 mmol), and 7-chloro-4-(piperazin-1-yl)quinoline (124 mg, 0.5 mmol) are treated according to method D delivering 147 mg of the product as a pale yellow solid after column chromatography with hexane-EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-6fda6e1b6d514a21b20a25cdcb19dbe5 |
| Source note | uspto-grants-2007_05 |