HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 7-Chloro-4-[4-(1,2,3,4-tetrahydronaphth-1-ylaminocarbonyl)piperazin-1-yl]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,2,3,4-Tetrahydro-1-naphthylamine | HCID 18066 | — |
| Reactant | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| Reactant | 7-Chloro-4-(piperazin-1-yl)quinoline | HCID 738389 | — |
| Product | 7-Chloro-4-[4-(1,2,3,4-tetrahydronaphth-1-ylaminocarbonyl)piperazin-1-yl]quinoline | HCID 21101751 | — |
Reaction Steps
1,2,3,4-Tetrahydronaphthylamine (36 μL, 0.25 mmol), 4-nitrophenyl chloroformate (51 mg, 0.25 mmol), triethylamine (140 μL, 1.0 mmol), and 7-chloro-4-(piperazin-1-yl)quinoline (62 mg, 0.25 mmol) are treated according to method D delivering the title product as a colorless oil after column chromatography with hexane-EtOAc.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-3d3d41ad5ea44df280e3a1ac65b878cb |
| Source note | uspto-grants-2007_05 |