4-Fluorobenzylamine → HCID 178512312, compound

HRID 1353395Notes

Reaction equation

HRID 1353395 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:18](=[N:26][C:27]#[N:28])OC4C=CC=CC=4)[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[F:29][C:30]1[CH:37]=[CH:36][C:33]([CH2:34][NH2:35])=[CH:32][CH:31]=1>N1C=CC=CC=1>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:13][CH2:14][N:15]([C:18](=[N:26][C:27]#[N:28])[NH:35][CH2:34][C:33]4[CH:36]=[CH:37][C:30]([F:29])=[CH:31][CH:32]=4)[CH2:16][CH2:17]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 673264-FluorobenzylamineHCID 87869961HCID 87869961, compound

Product 1

HCID 178512312HCID 178512312, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

7-Chloro-4-[4-(cyanimino(phenoxy)methyl)piperazin-1-yl]quinoline (107 mg, 0.27 mmol) and 4-fluorobenzylamine (62 μL, 0.54 mmol) are heated in pyridine (10 mL) for 3 h at reflux. The solvent is removed, and the residue purified by column chromatography with CH2Cl2-MeOH giving the title product as a colorless solid.

Workup

  1. temperatureat reflux
  2. customThe solvent is removed
  3. customthe residue purified by column chromatography with CH2Cl2-MeOH giving the title product as a colorless solid

Sources & evidence

ORD record
ord-b00670d3585549e9bbe7bad222dde38e
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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