Ethylamine hydrochloride → HCID 178464572, compound

Participants

Reaction Steps

7-Chloro-4-[4-(cyanimino(phenoxy)methyl)piperazin-1-yl]quinoline (0.39 g, 1.0 mmol), ethylamine hydrochloride (1.68 g, 20.6 mmol), and diaza[2.2.2]bicyclooctane (2.24 g, 20.0 mmol) in isopropanol (20 mL) are heated in a sealed tube for 4 h at 110° C. The reaction mixture is concentrated, and the residue is suspended in EtOAc. Washing with water, drying (MgSO4), and removing the solvent leads to a colorless solid, which is washed with hot ether to yield the title product.

Provenance & Evidence