HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Chloro-4-(piperazin-1-yl)quinoline → HCID 178502862, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Chloro-4-(piperazin-1-yl)quinoline | HCID 738389 | — |
| Reactant | HCID 21101973 | HCID 21101973 | — |
| Reactant | Sodium periodate | HCID 23667635 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| Product | HCID 178502862 | HCID 178502862 | — |
Reaction Steps
7-Chloro-4-(piperazin-1-yl)quinoline (297 mg, 1.2 mmol), N-(4-Fluorophenyl)-N′-methoxythiourea (240 mg, 1.2 mmol), and sodium periodate (278 mg, 1.3 mmol) in DMF-water 1:1 (40 mL) are heated at 85° C. for 1 h. The reaction mixture is diluted with water and extracted with ether. The organic phase is dried (MgSO4) and concentrated. The residue is purified by column chromatography with hexane-EtOAc yielding the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-1a7ff1c4d8314b9d83859f37678ba419 |
| Source note | uspto-grants-2007_05 |