4-Fluorobenzylamine → HCID 178512107, compound

HRID 1353404Notes

Reaction equation

HRID 1353404 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:18]#[N:19])[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[F:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25][NH2:26])=[CH:23][CH:22]=1>FC(F)(F)C(O)C(F)(F)F>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:13][CH2:14][N:15]([C:18]([NH:26][CH2:25][C:24]4[CH:27]=[CH:28][C:21]([F:20])=[CH:22][CH:23]=4)=[NH:19])[CH2:16][CH2:17]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 673264-FluorobenzylamineHCID 21101963HCID 21101963, compound

Product 1

HCID 178512107HCID 178512107, compound

Reagents, catalysts & solvents 1

HCID 135291,1,1,3,3,3-Hexafluoro-2-propanolSolvent

Procedure

7-Chloro-4-(4-cyanopiperazin-1-yl)quinoline (219 mg, 0.8 mmol) and 4-fluorobenzylamine (114 μL, 1.0 mmol) in 1,1,1,3,3,3-hexafluoro-2-propanol (5 mL) are heated at 130° C. in a sealed tube for 44 h. The reaction mixture is concentrated, and the residue is purified by column chromatography with CH2Cl2—NH3-MeOH to give the title product as a yellow foam.

Workup

  1. concentrationThe reaction mixture is concentrated
  2. customthe residue is purified by column chromatography with CH2Cl2—NH3-MeOH

Sources & evidence

ORD record
ord-25d343da95ac445b9b751536c42947f6
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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