反应详情

7-Chloro-4-(4-cyanopiperazin-1-yl)quinoline (150 mg, 0.55 mmol) and 4-fluoroaniline (66 μL, 0.7 mmol) in 1,1,1,3,3,3-hexafluoro-2-propanol (5 mL) are heated at 150° C. in a sealed tube for 66 h. The reaction mixture is concentrated, and the residue is purified by column chromatography with CH2Cl2—NH3-MeOH to give the title product as a colorless foam.

1. concentrationThe reaction mixture is concentrated
2. customthe residue is purified by column chromatography with CH2Cl2—NH3-MeOH