Tetrahydrofuran → HCID 21101581, compound

Participants

Reaction Steps

To 7-Chloro-4-[4-(4-fluorphenylaminocarbonyl)piperazin-1-yl]-2-[2-(trifluoroacetamino)ethylamino]quinoline (13 mg, 0.024 mmol) was added THF (0.5 mL) and 0.5 N KOH (2.0 eq, 0.14 mL), the mixture was stirred at rt. for 2 h, additional 0.5 N KOH (0.5 mL, 10 eq.) was added and the reaction mixture was heated at 50° C. for 30 min, MeOH (0.2 ml) was added and heated at the same temperature for 30 min. Evaporation and dilution with AcOEt, washing with brine, usual workup gave the residue, which was purified by preparative TLC with 20% MeOH in DCM with 0.5% hydroxylamine by twice developing the plate to afford the title compound.

Provenance & Evidence