HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 4-(7-Chloro-4-quinolinyl)-N-[4-(trifluoromethyl)cyclohexyl]-1-piperazinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| Reactant | 7-Chloro-4-(piperazin-1-yl)quinoline | HCID 738389 | — |
| Reactant | cis-4-(Trifluoromethyl)cyclohexylamine | HCID 13714353 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 4-(7-Chloro-4-quinolinyl)-N-[4-(trifluoromethyl)cyclohexyl]-1-piperazinecarboxamide | HCID 21101729 | — |
Reaction Steps
As described for example 78, 4-trifluoromethyl cyclohexyl amine, 4-nitrophenyl chloroformate, diisopropyl(ethyl)amine, and 7-chloro-4-(piperazin-1-yl)quinoline are reacted to afford the product after flash chromatography with CH2Cl2-MeOH. LC-MS: 441 (M++1). 1H NMR (CDCl3) δ 8.78 (d, 1H), 8.05 (s, 1H), 7.95 (d, 1H), 7.46 (d, 1H), 6.85 (d, 1H), 4.60 (d, 1H), 4.03 (m, 1H), 3.65 (m, 4H), 3.20 (m, 4H), 2.10 (m, 1H), 1.85 (m, 4H), 1.50–1.70 (m, 4H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-3bf660344e534bd49abbe9af16720a11 |
| Source note | uspto-grants-2007_05 |