Diisopropylethylamine → HCID 178461368, compound

Participants

Reaction Steps

As described for example 78, trans-4-methyl-1-cyclohexanamine (170 mg, 1.5 mmol) prepared in a similar manner as for cis-4-methyl-1-cyclohexanamine, 4-nitrophenyl chloroformate (302 mg, 1.5 mmol), diisopropyl(ethyl)amine (258 mg, 2 mmol), and 7-chloro-4-(piperazin-1-yl)quinoline (248 mg, 1 mmol) are reacted affording the title product after flash chromatography with CH2Cl2-MeOH. 1H NMR (DSMO-d6) δ 0.9 (d, 3H), 1.0–1.2 (m, 3H), 1.23–1.4 (m, 2H), 1.7 (m, 2H), 2.02 (m, 2H), 3.2 (m, 4H), 3.61 (m, 4H), 4.38 (m, 1H), 6.83 (d, 1H), 7.43 (d, 1H), 7.94 (d, 1H), 8.05 (s, 1H), 8.77 (d, 1H).

Provenance & Evidence