Boron tribromide → HCID 21101712, compound

Participants

Reaction Steps

To a stirred solution of 4-(7-chloro-4-quinolinyl)-N-(2-methoxyphenyl)-1-piperazine carboxamide (40 mg, 0.1 mmol) in CH2Cl2 (6 mL) was added a solution of BBr3 (0.2 mL, 1.0 M) at rt. The reaction mixture was stirred at rt overnight, then quenched with 1 N NaOH solution. The reaction mixture was extracted with CH2Cl2, washed with brine, and dried over Na2SO4. Concentration in vacuo followed by flash chromatography afforded the title product. LC-MS 383 (M++1). 1H NMR (CDCl3) δ 8.75 (d, 1H), 8.05 (s, 1H), 7.95 (d, 1H), 7.45 (d, 1H), 7.05 (m, 3H), 6.85 (m, 2H), 6.70 (s, 1H), 3.85 (m, 4H), 3.30 (m, 4H).

Provenance & Evidence