Lithium Hydroxide → HCID 58864190, compound

Participants

Reaction Steps

To a stirred solution of N-[9-(acetyloxy)-2-fluoro-6,7,8,9-tetrahydro-5H-benzo[α]cyclohepten-7-yl]-4-(7-chloro-4-quinolinyl)-1-piperazinecarboxamide (30.0 mg, 0.0588 mmol) in THF:H2O (3:1, 2 mL) was added LiOH (8 mg). The reaction mixture was stirred at rt for 3 h, then THF was evaporated in vacuo. The reaction mixture was diluted with AcOEt (100 mL), washed with brine, and dried. Concentration followed by flash chromatography afforded the title product. LC-MS: 469 (M++1). δ 1H NMR (CDCl3) δ 8.70 (d, 1H), 8.05 (s, 1H), 7.95 (d, 1H), 7.45 (d, 1H), 7.05 (m, 2H), 6.85 (m, 2H), 4.95 (m, 1H), 4.35 (m, 1H), 3.65 (m, 4H), 3.20 (m, 4H), 3.15 (m, 1H), 2.60 (m, 1H), 2.20 (m, 2H), 1.8 (m, 3H).

Provenance & Evidence