Sodium hydride → HCID 21101717, compound

Participants

Reaction Steps

As described for example 138, 4-(7-chloro-4-quinolinyl)-N-(3-hydroxycycloheptyl)-1-piperazinecarboxamide (50 mg, 0.124 mmol), NaH (8.9 mg, 0.37 mmol), and 4-fluorobenzyl bromide (28.2 mg, 0.15 mmol) are reacted to give the title product after flash chromatography with CH2Cl2-MeOH. LC-MS: 511 (M++1). 1H NMR (CDCl3) δ 8.75 (d, 1H), 8.05 (s, 1H), 7.95 (d, 1H), 7.45 (d, 1H), 7.35 (m, 2H), 7.00 (m, 2H), 6.85 (d, 1H), 4.50 (m, 2H), 4.40 (m, 1H), 4.10 (m, 1H), 3.65 (m, 4H), 3.20 (m, 4H), 2.20 (m, 1H), 2.10 (m, 1H), 1.50–1.90 (m, 6H), 1.40 (m, 2H).

Provenance & Evidence