Sodium hydride → HCID 21101715, compound

Participants

Reaction Steps

As described for example 138, 4-(7-chloro-4-quinolinyl)-N-(3-hydroxycycloheptyl)-1-piperazinecarboxamide, NaH, and 2-bromo-3-picoline are reacted to give the product. LC-MS: 494 (M++1). 1H NMR (CDCl3) δ 8.75 (d, 1H), 8.05 (s, 1H), 7.98 (d, 1H), 7.85 (m, 1H), 7.45 (d, 1H), 7.40 (m, 1H), 6.85 (d, 1H), 6.78 (m, 1H), 6.10 (d, 1H), 5.20 (m, 1H), 4.10 (m, 1H), 3.76 (m, 4H), 3.25 (m, 4H), 2.26 (m, 1H), 2.18 (s, 3H), 2.12 (m, 2H), 1.45–1.90 (m, 7H).

Provenance & Evidence