HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → HCID 21101670, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 58864188 | HCID 58864188 | — |
| Product | HCID 21101670 | HCID 21101670 | — |
Reaction Steps
As described for example 171, [[[4-(2-amino-7-chloro-4-quinolinyl)-1-piperazinyl]carbonyl]amino]-acetic acid, di-methylamine, iPr2NEt, and HATU are reacted to afford the product. LC-MS: 390 (M++1). 1H NMR (CDCl3): δ 3.05 (s, 6H), 3.1–3.2 (m, 4H), 3.6–3.8 (m, 4H), 4.05–4.15 (d, 2H), 4.9–5.0 (s, H), 5.8 (m, 1H), 6.1–6.2 (s, 1H), 7.1–7.2 (m, 1H), 7.6 (m, 1H), 7.7–7.8 (m, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-3dd784f9bf814e58b3a8bcaa9dbd35ce |
| Source note | uspto-grants-2007_05 |