Sodium Hydroxide → HCID 10480044, compound

Participants

Reaction Steps

To a stirred solution of (3S)-[[[4-(2-amino-7-chloro-4-quinolinyl)-1-piperazinyl]carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-acetic acid, methyl ester (300 mg, 0.613 mmol) in THF (3.0 mL) was added 2N NaOH solution (3 mL) at rt. After 30 min, THF was evaporated in vacuo, and the resulting residue was acidified to pH 4–5. The reaction mixture was extracted with ethyl acetate, washed with brine, and dried over Na2SO4. The product (15 mg) was obtained after concentration in vacuo. LC-MS: 475 (M++1). 1H NMR (CD3OD) δ 7.82 (d, 1H), 7.50 (s, 1H), 7.38 (d, 1H), 6.25 (s, 1H), 4.58 (d, 1H), 4.10 (m, 2H), 3.80 (m, 1H), 3.65 (m, 4H), 3.30 (m, 5H), 1.60–1.96 (m, 6H).

Provenance & Evidence