HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → HCID 10347873, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 10480044 | HCID 10480044 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 10347873 | HCID 10347873 | — |
Reaction Steps
The mixtures of (3S)-[[[4-(2-amino-7-chloro-4-quinolinyl)-1-piperazinyl]carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-acetic acid (50.0 mg, 0.1 mmol), benzyl amine (0.2 mL), HATU (50 mg), and diisopropylethyl amine (0.3 mL) in DMF (5 mL) was stirred at rt for 2 h. The reaction mixture was diluted with ethyl acetate (100 mL), washed with NaHCO3 (sat.) and water, dried over Na2SO4. Concentration in vacuo followed by flash chromatography afforded the title product. LC-MS: 564 (M++1). 1H NMR (CD3OD) δ 7.82 (d, 1H), 7.45 (s, 1H), 7.25 (m, 4H), 7.20 (m, 2H), 6.30 (s, 1H), 4.65 (d, 1H), 4.40 (s, 2H), 4.15 (m, 2H), 3.75 (m, 1H), 3.65 (m, 4H), 3.30 (m, 1H), 3.10 (m, 4H), 1.96 (m, 2H), 1.80 (m, 2H), 1.60 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-c63f2b645e17404b8448a0606247dcb2 |
| Source note | uspto-grants-2007_05 |