HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → HCID 10368202, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 10480044 | HCID 10480044 | — |
| Product | HCID 10368202 | HCID 10368202 | — |
Reaction Steps
As described as example 208, (3S)-[[[4-(2-amino-7-chloro-4-quinolinyl)-1-piperazinyl]carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-acetic acid, methyl amine, HATU, and diisopropylethylamine are reacted to afford the product. LC-MS 488 (M++1). 1H NMR (CD3OD) δ 7.86 (d, 1H), 7.50 (s, 1H), 7.30 (d, 1H), 6.30 (s, 1H), 4.65 (m, 1H), 4.00 (m, 2H), 3.70 (m, 5H), 3.30 (m, 5H), 2.75 (s, 3H), 1.98 (m, 2H), 1.80 (m, 2H), 1.60 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220856B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-505fa2afebc041b3a4153a9f31f0bb50 |
| Source note | uspto-grants-2007_05 |