4-Aminopyridine → HCID 10370331, compound

Participants

Role	Name	HCID	Charge
Reactant	4-Aminopyridine	HCID 1727	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Reactant	HCID 10480044	HCID 10480044	—
Product	HCID 10370331	HCID 10370331	—

Reaction Steps

As described as example 208, (3S)-[[[4-(2-amino-7-chloro-4-quinolinyl)-1-piperazinyl]carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-acetic acid, 4-aminopyridine, HATU, and diisopropylethylamine are reacted to afford the product. LC-MS: 551 (M++1). 1H NMR (CD3OD) δ 1.60–1.80 (m, 4H), 1.90 (m, 2H), 3.10 (m, 4H), 3.30 (m, 1H), 3.60 (m, 4H), 4.20 (m, 2H), 4.60 (d, 1H), 6.24 (s, 1H), 7.08 (d, 1H), 7.39 (s, 1H), 7.55 (m, 2H), 7.75 (d, 2H), 8.30 (m, 2H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07220856B2
Source dataset	uspto-grants-2007_05
ORD ID	ord-d3bc2a21f7dc4747a5724398dbf774e0
Source note	uspto-grants-2007_05