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Diisopropylethylamine → 4-[7-Chloro-2-(methylamino)-4-quinolinyl]-N-[(3S)-hexahydro-2-oxo-1H-azepin-3-yl]-1-piperazinecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| 反応物 | L-2-aminohexano-6-lactam | HCID 440599 | — |
| 反応物 | 7-Chloro-4-(1-piperazinyl)-2-quinolinamine | HCID 21101748 | — |
| 生成物 | 4-[7-Chloro-2-(methylamino)-4-quinolinyl]-N-[(3S)-hexahydro-2-oxo-1H-azepin-3-yl]-1-piperazinecarboxamide | HCID 10388008 | — |
反応手順
As described for example 78, (3S)-3-aminohexahydro-2H-azepin-2-one, 4-nitrophenyl chloroformate, diisopropyl(ethyl)amine, and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product as a light yellow solid. LC-MS: 431 (M++1). 1H NMR (CDCl3): δ 1.34˜1.60 (m, 2H), 1.80˜1.92 (m, 2H), 1.98˜2.08 (m, 1H), 2.10˜2.18 (m, 1H), 3.06 (d, 3H), 3.12 (br.s, 4H), 3.20˜3.38 (m, 2H), 3.67 (br.s, 4H), 4.52 (br. dd, 1H), 5.98˜6.06 (m, 2H), 6.12 (d, 1H), 7.12 (dd, 1H), 7.67 (d, 1H), 7.70 (d, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07220856B2 |
| 出典データセット | uspto-grants-2007_05 |
| ORD ID | ord-eef42cbb1adf4db49cef4e32947f7b00 |
| 出典メモ | uspto-grants-2007_05 |