Trifluoroacetic acid → HCID 11756931, compound

Participants

Reaction Steps

As described for example 213, [(3S)-hexahydro-2-oxo-1-(phenylacetyl)-1H-azepin-3-yl]-carbamic acid, 1,1-dimethylethyl ester, TFA, triphosgene, NaHCO3 (sat.), and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product as a light yellow solid. LC-MS: 535 (M++1). 1H NMR (CDCl3, 400 MHz): δ 1.20˜1.50 (m, 2H), 1.80˜2.20 (m, 4H), 3.10˜3.20 (m, 5H), 3.60˜3.70 (m, 4H), 4.28 (AB, 2H), 4.75 (dd, 1H), 4.80˜4.95 (m, 3H), 5.85 (d, 1H), 6.16 (s, 1H), 7.18 (dd, 1H), 7.22˜7.36 (m, 5H), 7.62 (d, 1H), 7.72 (d, 1H).

Provenance & Evidence