Trifluoroacetic acid → HCID 10433621, compound

Participants

Reaction Steps

As described for example 213, [(3R)-1-formylhexahydro-2-oxo-1H-azepin-3-yl]-carbamic acid-1,1-dimethylethyl ester, TFA, triphosgene, NaHCO3 (sat.), and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product as a light yellow solid. LC-MS: 445 (M++1). 1H NMR (CDCl3): δ 1.30 (m, 1H), 1.65 (m, 1H), 1.80˜2.30 (m, 4H), 3.09 (dd, 1H), 3.14 (m, 4H), 3.68 (m, 4H), 4.62 (br.dd, 1H), 4.82 (ddd, 1H), 4.90 (br.s, 2H), 5.84 (d, 1H), 6.16 (s, 1H), 7.18 (dd, 1H), 7.62 (d, 1H), 7.72 (d, 1H), 9.47 (s, 1H).

Provenance & Evidence