Trifluoroacetic acid → HCID 10413663, compound

Participants

Reaction Steps

As described for example 213, [(3R)-1-(2,2-dimethyl-1-oxopropyl)hexahydro-2-oxo-1H-azepin-3-yl]-carbamic acid-1,1-dimethylethyl ester, TFA, triphosgene, NaHCO3 (sat.), and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product as a light yellow solid. LC-MS: 501 (M++1). 1H NMR (CDCl3) δ 1.30 (s, 9H), 1.50˜1.70 (m, 1H), 1.80˜2.08 (m, 3H), 2.10–2.20 (m, 1H), 3.05˜3.20 (m, 4H), 3.45 (dd, 1H), 3.60–3.74 (m, 4H), 3.80 (br.dd, 1H), 4.66 (m, 1H), 4.94 (br.s, 2H), 5.96 (d, 1H), 6.15 (s, 1H), 7.16 (dd, 1H), 7.60 (d, 1H), 7.71 (d, 1H).

Provenance & Evidence