Trifluoroacetic acid → HCID 9983235, compound

Participants

Reaction Steps

As described for example 213, [(3R)-hexahydro-1-(methylsulfonyl)-2-oxo-1H-azepin-3-yl]-carbamic acid-1,1-dimethylethyl ester, TFA, triphosgene, NaHCO3 (sat.), and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product as a light yellow solid. LC-MS: 495 (M++1). 1H NMR (CDCl3) δ 1.52 (m, 1H), 1.70 (m, 1H), 1.86 (m, 1H), 1.95˜2.05 (m, 2H), 2.15 (m, 1H), 3.09 (m, 4H), 3.45 (s, 3H), 3.48 (m, 1H), 3.65 (m, 4H), 4.45 (m, 1H), 4.81 (m, 1H), 5.17 (br.s, 2H), 5.95 (d, 1H), 6.15 (s, 1H), 7.15 (dd, 1H), 7.60 (d, 1H), 7.69 (d, 1H).

Provenance & Evidence