Trifluoroacetic acid → HCID 9982977, compound

Participants

Reaction Steps

As described for example 213, (3R)-3-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-carboxylic acid, ethyl ester, TFA, triphosgene, NaHCO3 (sat.), and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the title product as a light yellow solid. LC-MS: 489 (M++1). 1H NMR (CDCl3): δ 1.37 (t, 3H), 1.44˜2.02 (m, 5H), 2.12˜2.20 (m, 1H), 3.13 (m, 4H), 3.41 (dd, 1H), 3.67 (m, 4H), 4.35 (m, 2H), 4.42 (m, 1H), 4.74˜4.86 (m, 3H), 6.00 (d, 1H), 6.16 (s, 1H), 7.18 (dd, 1H), 7.62 (d, 1H), 7.73 (d, 1H).

Provenance & Evidence