Trifluoroacetic acid → HCID 10482483, compound

Participants

Reaction Steps

As described for example 213, (3R)-3-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-carboxylic acid, 2,2,2-trifluoroethyl ester, TFA, triphosgene, NaHCO3 (sat.), and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product as a white solid. LC-MS: 543 (M++1). 1H NMR (DMSO+TFA): δ 1.32–1.45 (m, 1H), 1.56˜1.90 (m, 5H), 3.26 (m, 4H), 3.54–3.66 (m, 5H), 4.15 (m, 1H), 4.68 (br.d, 1H), 4.83 (m, 2H), 6.32 (s, 1H), 7.42 (dd, 1H), 7.60 (d, 1H), 7.90 (d, 1H).

Provenance & Evidence