Trifluoroacetic acid → HCID 10007857, compound

Participants

Reaction Steps

As described for example 213, (3R)-3-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-carboxylic acid-4-fluorophenyl ester, TFA, triphosgene, NaHCO3 (sat.), and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product as a light yellow solid. LC-MS: 555 (M++1). 1H NMR (CDCl3): δ 1.54˜2.10 (m, 5H), 2.16–2.24 (m, 1H), 3.14 (m, 4H), 3.54 (dd, 1H), 3.68 (m, 4H), 4.52 (dd, 1H), 4.84 (br.s, 2H), 4.90 (ddd, 1H), 5.94 (d, 1H), 6.15 (s, 1H), 7.06–7.13 (m, 2H), 7.13–7.20 (m, 3H), 7.62 (d, 1H), 7.72 (d, 1H).

Provenance & Evidence