Trifluoroacetic acid → HCID 10389500, compound

Participants

Reaction Steps

As described for example 213, [(3S)-1-(aminocarbonyl)hexahydro-2-oxo-1H-azepin-3-yl]-carbamic acid-1,1-dimethylethyl ester, TFA, triphosgene, NaHCO3 (sat.), and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product as a white solid. LC-MS: 460 (M++1). 1H NMR (DMSO-d6+TFA): 1.16˜1.30 (m, 1H), 1.54˜1.88 (m, 5H), 3.26 (m, 4H), 3.60 (m, 4H), 4.56 (ddd, 1H), 4.70 (br.dd, 1H), 6.32 (s, 1H), 7.38–7.46 (m, 2H), 7.62 (d, 1H), 7.88 (d, 1H), 8.20–8.50 (m, 3H).

Provenance & Evidence