Trifluoroacetic acid → HCID 58864158, compound

Participants

Reaction Steps

As described for example 213, [(3R)-hexahydro-2-oxo-1-[[(2,2,2-trifluoroethyl)amino]carbonyl]-1H-azepin-3-yl]-carbamic acid, 1,1-dimethylethyl ester, TFA, triphosgene, NaHCO3 (sat.), and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product as a light yellow solid. LC-MS: 542 (M++1). 1H NMR (CDCl3,): δ 1.44 (m, 1H), 1.64 (m, 1H), 1.82˜2.02 (m, 4H), 3.14 (m, 4H), 3.31 (dd, 1H), 3.68 (m, 4H), 3.98 (m, 2H), 4.84 (dd, 1H), 4.88–5.00 (m, 3H), 5.80 (d, 1H), 6.03 (s, 1H), 7.16 (dd, 1H), 7.60 (d, 1H), 7.71 (d, 1H), 9.54 (t, 1H).

Provenance & Evidence