Trifluoroacetic acid → HCID 10436495, compound

Participants

Reaction Steps

As described example 78, (3R)-3-amino-N-cyclobutylhexahydro-2-oxo-1H-azepine-1-carboxamide by de-protection of [(3S)-1-[(cyclobutylamino)carbonyl]hexahydro-2-oxo-1H-azepin-3-yl] carbamic acid-1,1-dimethylethyl ester with TFA, p-nitrophenyl chloroformate, diisopropyl(ethyl)amine, and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product. 1HNMR (DMSO-d6): δ 1.24 (br. s, 1H), 1.5–1.9 (m, 7H), 2.2 (m, 2H), 2.99 (m, 4H), 3.6 (m, 4H), 4.17 (m, 1H), 4.52 (m, 1H), 4.66 (t, 1H), 6.14 (s, 1H, 6.42 (br. s, 1H), 6.8 (d, 1H), 7.1 (d, 1H), 7.39 (s, 1H), 7.76 (d, 1H), 9.3 (d, 1H).

Provenance & Evidence