1,4'-Bipiperidine → HCID 58864471, compound

Participants

Reaction Steps

To a solution of (R)-2-{[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidine-1-carbonyl]-amino}-3-[1-(2-trimethylsilanyl-ethanesulfonyl)-1H-indazol-5-yl]-propionic acid (554 mg, 0.88 mmol) and N,N-diisopropylethylamine (0.62 mL, 3.54 mmol) in methylene chloride (20 mL) was added a solution of 4-piperidinopiperidine (164 mg, 0.97 mmol) and PyBOP® (460 mg, 0.88 mmol) in methylene chloride (15 mL). The reaction mixture was stirred for 16 h at room temperature. It was then concentrated to approximately 2 mL and subjected to flash column chromatography using methylene chloride/methanol/triethylamine (94:5:1) as eluent to give 599 mg (87%) of the title compound as a white solid. 1H-NMR (CD3CN, 300 MHz) δ 8.37 (s, 0.5H), 8.36 (s, 0.5H), 8.02–7.96 (m, 1H), 7.74 (s, 0.5H), 7.71 (s, 0.5H), 7.55–7.46 (m, 1H), 7.21–7.12 (m, 2H), 6.97–6.92 (m, 1H), 6.79 (d, J=8.1 Hz, 1H), 5.71 (t, J=8.1 Hz, 1H), 5.00 (dd, J=15.0, 8.1 Hz, 1H), 4.63–4.51 (m, 1H), 4.39–4.29 (m, 1H), 4.29 (s, 2H), 4.10–3.96 (m, 3H), 3.46–3.40 (m, 2H), 2.92–2.70 (m, 8H), 2.58–2.37 (m, 5H), 1.74–1.40 (m, 13H), 0.80–0.74 (m, 2H), −0.04 (s, 9H). Mass spec.: 778 (MH)+.

Provenance & Evidence