反应详情

温度

0 °C

Into a flame dried flask, N-(1-benzyl-piperidin-4-yl)-2-(2-nitro-phenyl)-acetamide (3.2 g, 9.06 mmol) and lithium aluminium hydride (1.0 g, 18.12 mmol) were combined. 1,4-Dioxane (15 mL) was added and the mixture slowly brought to reflux over 1 h and stirred at reflux for 16 h. The reaction mixture was cooled to 0° C. and excess lithium aluminium hydride destroyed by dropwise addition of methanol, followed by careful addition of 20% potassium hydroxide. The aluminum salts were filtered, the filtrate concentrated and used as is for the next reaction.

1. customInto a flame dried flask
2. temperatureto reflux over 1 h
3. temperatureat reflux for 16 h
4. customexcess lithium aluminium hydride destroyed by dropwise addition of methanol
5. additionfollowed by careful addition of 20% potassium hydroxide
6. filtrationThe aluminum salts were filtered
7. concentrationthe filtrate concentrated
8. customas is for the next reaction