2-Butanone, 3-bromo- → 6,8-Dibromo-2,3-dimethylimidazo[1,2-a]pyridine

Participants

Reaction Steps

A mixture of 31.8 g of 2-amino-3,5-dibromopyridine, 22 g of 3-bromo-2-butanone and 350 ml of tetrahydrofuran is heated at reflux for 9 days and the resulting precipitate is filtered off and dried under reduced pressure. The precipitate is then suspended in 1 l of water, and the suspension is adjusted to pH 8 using 6 M aqueous sodium hydroxide solution. The resulting precipitate is filtered off and washed with water. This gives 28 g of the title compound of m.p. above 90° C. (sinters).

Provenance & Evidence