Sodium Iodide → HCID 9807547, compound

Participants

Reaction Steps

A mixture of N-(2-chloroacetyl)-4-[2-(3-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]benzenesulfonamide (0.1 g 0.2 mmol), diethylamine (0.073 g 1 mmol) and sodium iodide (0.005 g 0.03 mmol) in dry THF (5 ml) was stirred at room temperature for 24 hr. The solvent was removed and the residues partitioned between ethyl acetate (10 ml) and water (10 ml). The organic layer was dried (MgSO4), the solvent removed and the residues were purified by SPE chromatography using a cartridge containing an ion exchange sorbent that retains amino functionality. Elution with 5% acetic acid in methanol, ethyl acetate then 2M ammonia in methanol gave the title compound as a yellow solid (0.066 g 60%). MH+: 549

Provenance & Evidence