Hydrochloric Acid → HCID 21104472, compound

Participants

Reaction Conditions

Reaction Steps

14 mg of ethyl 8-(4-tert-butoxycarbonylamino-3,5-dimethylphenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylate (Example 12) was dissolved in 1 ml of THF. 1 ml of 3 N hydrochloric acid was added to the obtained solution, and they were stirred at 50° C. for 3 hours. 2 ml of 3 N sodium hydroxide was added to the reaction mixture, and they were stirred at 50° C. for 14 hours and then neutralized with 1 N hydrochloric acid. The crystals thus precipitated were taken by the filtration to obtain 4 mg of 8-(4-amino-3,5-dimethylphenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid.

Provenance & Evidence