反应详情

温度

75 °C

To a solution of (4-isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl -phenyl)-methanone (3.0 g, 9.05 mmol) in absolute EtOH (20 mL) was added, via an addition funnel, a solution of maleic acid (3.3 g, 19.8 mmol) in absolute EtOH (20 mL) over 10 min. The resulting suspension was stirred at room temperature for 15 min, at 75° C. for 30 min, and was then allowed to cool to room temperature for 15 h. The reaction mixture was cooled further to 0° C. and was then stirred for 2 h. The resulting precipitate was collected by suction filtration and washed with cold EtOH (20 mL). The wet solid was dried in a vacuum oven at 40° C. for 6 h to yield the title compound as crude material, as a white solid.

1. temperatureto cool to room temperature for 15 h
2. temperatureThe reaction mixture was cooled further to 0° C.
3. stirringwas then stirred for 2 h
4. filtrationThe resulting precipitate was collected by suction filtration
5. washwashed with cold EtOH (20 mL)
6. customThe wet solid was dried in a vacuum oven at 40° C. for 6 h