Methanol → HCID 178453956, compound

Participants

Reaction Conditions

Reaction Steps

A solution of borane dimethyl sulphide complex (2.85 ml, 30 mmol) in THF (50 ml) was added dropwise at 0° C. to a solution of trans-4-tert-butoxycarbonylamino-cyclohexanecarboxylic acid (2.43 g, 10 mmol) in THF (100 ml). The reaction mixture was stirred at 0° C. for 15 minutes and at room temperature for 3 hours, methanol was cautiously added and the mixture was concentrated. The crude product was repeatedly treated with methanol and concentrated again, and finally dried under a high vacuum. Used without further purification.

Provenance & Evidence