HCID 11298596, compound → HCID 21104595, compound

HRID 1354234Notes

Reaction equation

HRID 1354234 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][NH:12][CH2:13][C:14]3[CH2:15][NH:16][CH2:17][CH2:18][CH:19]=3)=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1.[CH3:20][O:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[N:28]=[CH:27][CH:26]=[C:25]2[CH:32]1[CH2:34][O:33]1>CCO>[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][NH:12][CH2:13][C:14]3[CH2:15][N:16]([CH2:34][CH:32]([C:25]4[C:24]5[C:29](=[CH:30][CH:31]=[C:22]([O:21][CH3:20])[CH:23]=5)[N:28]=[CH:27][CH:26]=4)[OH:33])[CH2:17][CH2:18][CH:19]=3)=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 11298596HCID 11298596, compoundHCID 21104576HCID 21104576, compound

Product 1

HCID 21104595HCID 21104595, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of (2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-(1,2,5,6-tetrahydro-pyridin-3-ylmethyl)-amine (0.06 g, 0.23 mmol) and 6-methoxy-4-oxiranylquinoline (0.06 g, 0.29 mmol) in EtOH (2 ml) was heated at 80° C. for 14 hours. The reaction mixture was concentrated and the residue was purified by chromatography on silica gel (DCM/MeOH 9/1).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by chromatography on silica gel (DCM/MeOH 9/1)

Sources & evidence

ORD record
ord-9f96611c45634a7cb2fa539c27bd6c0c
Source dataset
uspto-grants-2007_05
Patent number
US07223776B2

Reaction notes

Loading…