3-(Trifluoromethyl)benzylamine → HCID 32671870, compound

HRID 1354269Notes

Reaction equation

HRID 1354269 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][NH2:7].[F:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]2[C:24]([C:25]([F:28])([F:27])[F:26])=[C:23]([C:29](O)=[O:30])[CH:22]=[N:21]2)=[CH:16][CH:15]=1.N=C=N>C(Cl)Cl>[F:1][C:2]([F:11])([F:12])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][NH:7][C:29]([C:23]1[CH:22]=[N:21][N:20]([C:17]2[CH:18]=[CH:19][C:14]([F:13])=[CH:15][CH:16]=2)[C:24]=1[C:25]([F:28])([F:26])[F:27])=[O:30]

Participants

5

Reactant 3

HCID 759623-(Trifluoromethyl)benzylamineHCID 160435CarbodiimideHCID 50570101-(4-fluorophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Product 1

HCID 32671870HCID 32671870, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-Trifluoromethyl benzylamine (0.014 mL, 0.100 mmole) was added to a suspension of 1-(4-fluoro-phenyl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid (0.030 g; 0.109 mmol) and PS-Carbodiimide (0.2 g) in methylene chloride (2 mL). The reaction mixture was shaken at room temperature for 12 h at which time the reaction mixture was filtered and concentrated to give 1-(4-fluoro-phenyl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid 3-trifluoromethyl-benzylamide. LCMS m/z=432.3 (M+H)+.

Workup

  1. filtrationwas filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-38eff13061e94283a4969ba0f4f5fd13
Source dataset
uspto-grants-2007_05
Patent number
US07223782B2

Reaction notes

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