HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 21105105, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 3-Aminobenzene-1-sulfonyl fluoride | HCID 67780 | — |
| Reactant | 1-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride | HCID 2736645 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 21105105 | HCID 21105105 | 74.4% |
Reaction Steps
1-(4-Chloro-phenyl)-5-trifluoromethyl-1H-pyrazole-4-carbonyl chloride (3.00 g, 9.70 mmol) was added to 3-amino-benzenesulfonyl fluoride (1.87 g, 10.6 mmol) in CH2Cl2 (50 ml) containing pyridine (2.35 ml, 29.1 mmol). Reaction mixture stirred overnight at room temperature, concentrated under reduced pressure and crude product purified by column chromatography to give 3-{[1-(4-chloro-phenyl)-5-trifluoromethyl-1H-pyrazole-4-carbonyl]-amino}-benzenesulfonyl fluoride (3.23 g, 74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07223782B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-0a4e76a66c024c95a5f8d7a344581084 |
| Source note | uspto-grants-2007_05 |