Ethyl Acetate → HCID 58866146, compound

Participants

Reaction Steps

The above compound (4) (1.85 g) was dissolved in methanol (25 mL) and 28% NaOMe (668 mg) was added, and then the mixture was stirred at room temperature for 2 hours. Furthermore, 28% NaOMe (334 mg) was added and, after stirring at room temperature for 3 hours, the reaction solution was mixed with ethyl acetate (150 mL) and then washed with 0.5N hydrochloric acid and saturated saline. The organic layer was dried over magnesium sulfate and the solvent was distilled off under reduced pressure, and then the resulting residue was purified by silica gel medium pressure column chromatography (ethyl acetate:cyclohexane=2:3) to obtain the titled compound (1.36 g) as a syrup.

Provenance & Evidence