Methanol → HCID 21104868, compound

HRID 1354280Notes

Reaction equation

HRID 1354280 reaction equation
C(ON[C:10]([C@H:12]1[C@@H:17]([OH:18])[C@H:16]([OH:19])[C@@H:15]([OH:20])[CH2:14][N:13]1[S:21]([C:24]1[CH:29]=[CH:28][C:27]([O:30][CH2:31][CH2:32][O:33][CH2:34][CH3:35])=[CH:26][CH:25]=1)(=[O:23])=[O:22])=[O:11])C1C=CC=CC=1.C[OH:37]>[Pd]>[CH2:34]([O:33][CH2:32][CH2:31][O:30][C:27]1[CH:26]=[CH:25][C:24]([S:21]([N:13]2[CH2:14][C@H:15]([OH:20])[C@@H:16]([OH:19])[C@H:17]([OH:18])[C@@H:12]2[C:10]([OH:37])=[O:11])(=[O:22])=[O:23])=[CH:29][CH:28]=1)[CH3:35]

Participants

4

Reactant 2

HCID 887MethanolHCID 58866175HCID 58866175, compound

Product 1

HCID 21104868HCID 21104868, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Conditions

Temperature
40 °C

Procedure

The above compound (6) (1.66 g) was dissolved in methanol (70 mL) and 10% Pd—C (350 mg) was added, and then the mixture was stirred under a hydrogen atmosphere at 40° C. for one hour. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel medium pressure column chromatography (chloroform:methanol=10:1→5:1) to obtain the titled compound (815 mg) as a colorless powder.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe resulting residue was purified by silica gel medium pressure column chromatography (chloroform:methanol=10:1→5:1)

Sources & evidence

ORD record
ord-51af7403c5c84e8ea06b45b164de7a69
Source dataset
uspto-grants-2007_05
Patent number
US07223779B2

Reaction notes

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