Methanol → HCID 21104867, compound

Participants

Reaction Steps

The above compound (5) (8.68 g) was dissolved in methanol (350 mL) and a cation exchange resin (Muromac, 19.0 g) was added, and then the mixture was stirred overnight at room temperature. The insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel medium pressure column chromatography (chloroform:methanol=1:0→30:1→20:1→10:1) to obtain the titled compound (7.35 g) as a colorless powder.

Provenance & Evidence