HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanoacetamide → 2-Aminothiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,4-Dithiane-2,5-diol | HCID 98330 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Aminothiophene-3-carboxamide | HCID 699495 | 64% |
Reaction Steps
1,4-dithian-2,5-diol (4.56 g, 30 mmole) and 2-cyanoacetamide (2.52 g, 30 mmole) were combined in ethanol (50 ml). Added triethylamine (6 ml) and heated to 70° C. for 1 hour. Reduced the volume of solvent under vacuum, and isolated product by filtration. Product was recrystallized from ethanol to give 2.71 g product. (yield 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07223766B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-e5a4cd4a10b54243820facb3527fada7 |
| Source note | uspto-grants-2007_05 |