HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminopyridine → HCID 21104347, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminopyridine | HCID 1727 | — |
| Reactant | HCID 21104341 | HCID 21104341 | — |
| Catalyst | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 21104347 | HCID 21104347 | 81% |
Reaction Steps
4-Chloro-6-(2-fluoro-phenyl)-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidine (84 mg, 0.304 mmole) and 4-aminopyridine (57 mg, 0.608 mmole) were combined in 4 ml isopropanol, added 3 drops 4M HCl/dioxane and heated reaction mixture to 80° C. for 5 hours. Cooled reaction mixture and filtered product to obtain 83 mg after vacuum drying (yield: 81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07223766B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-4c85652654154e8faaa3c22642ece726 |
| Source note | uspto-grants-2007_05 |