2-Fluorobenzoyl chloride → HCID 21104353, compound

Participants

Reaction Conditions

Reaction Steps

5-Amino-1-butyl-3-methyl-1H-pyrazole-4-carbonitrile (10.0 g, 56 mmole) was dissolved in a mixture of dichloromethane/pyridine (45 ml/15 ml) and cooled to 0° C. 2-fluorobenzoyl chloride (8.87 g, 56 mmole) was added dropwise and reaction mixture stirred for 1 hour at 0° C., the at room temperature overnight. Removed solvent under vacuum. Residue was taken up in ethyl acetate, washed with dilute hydrochloric acid, 0.1M sodium hydroxide, water and dried over sodium sulfate (anh). Removed solvent and triturated solid in 30% ethyl acetate/hexanes. Filtered product to obtain 4.16 g product (yield: 24%).

Provenance & Evidence